Piceatannol1 is a metabolite of the powerful phytochemical resveratrol, which is a polyphenolic compound found in grape skins, bilberries, blueberries, cranberries and peanuts. Resveratrol has been studied for its effects on longevity, heart disease and cancer by its in-vitro ability to increase vasodilation and reduce platelet aggregation, oxidation and pro-inflammatory enzyme activity. The compound has increased the lifespan of yeast, worms and fruit flies.
Animal studies have been promising for the inhibition of some lines of cancer cell growth. Animal studies on heart disease have been mixed with high doses showing both benefit and harm.2 However, two of the worlds five documented zones of extreme longevity consume dark red wine that is very high in polyphenolic compounds including resveratrol. Once ingested, some resveratrol is converted to piceatannol.
Recently, researchers at Purdue University discovered that piceatannol blocks the development of immature fat cells into mature fat cells (a process called adipogenesis) by binding to their insulin receptors.3-4 Without insulin, the genes that promote the growth of baby fat cells (which cannot store fat) to adult fat cells (which can store fat) are never activated.
More research is needed and we won't be seeing any products anytime soon, but the beauty and simplicity of the process made it worth writing about. Needless to say, the implications for such a supplement are beyond huge. In the meantime, it's another reason to suggest your patients toss some red grapes and blueberries in their smoothies and protein shakes.
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Recent laws in New Jersey and California represent a disturbing trend that will negatively impact a practice’s ability to collect monies from patients, as well as expose them to significant penalties if the practice does not follow the mandatory guidelines to a T. Please be aware that a similar law may be coming to your state. The time to act is before the law is passed.
With estimates showing over 30 million Americans affected by peripheral neuropathy – and a significant portion underdiagnosed – it’s increasingly likely that chiropractors are already treating these patients. What’s missing is structured recognition, comprehensive management and targeted tools to slow progression, improve function and support systemic health.
Each year, ICD-10-CM is updated on Oct. 1. For 2026, there are 74,179 total codes, with 487 additions, 28 deletions and 38 revisions. Code changes are based on date of service, not the claim submission date. Services performed on/after Oct. 1 must use the new codes. While no changes affect the common spinal or extraspinal codes most frequently used by DCs, several updates may still affect your claims – particularly for comorbidities, referred pain, or trauma cases.
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