I recently read an article in the Journal of Orthopedic and Sports Physical Therapy that discusses an interesting situation we should all be aware of – deep-vein thrombosis (DVT) presenting as a calf strain.1 The case involved a 21-year-old runner who presented with a calf that felt tight and achy.
Ice, triceps surae stretches, a compression stocking and ibuprofen were prescribed. Three days later, he was 80 percent better and had no visible edema or ecchymosis; in fact, except for pain on palpation over the gastrocnemius and soleus, all previous positive tests were negative. I think most of us would agree with the diagnosis of a calf strain.
But four weeks later, the patient still felt a "low-intensity, nagging pain" in his left calf. An important finding regarding a possible deep-vein thrombosis was that the patient had experienced increased pain following a six-hour plane ride, causing him to seek help at a local emergency unit. He was told to use ice and stretching, which again relieved his symptoms. The main findings four weeks later, besides the pain after the plane ride, was that lower-leg edema was visible along with a 2+ pitting edema. All other previous tests were still normal.
|Pre-Test Probabilities of DVT5-6|
|Lower limb trauma or surgery or immobilization in a plaster cast||+1|
|Bedridden for more than three days or surgery within the last four weeks||+1|
|Tenderness along line of femoral or popliteal veins (not just calf tenderness)||+1|
|Entire limb swollen||+1|
|Calf more than 3 cm bigger circumference, 10 cm below tibial tuberosity||+1|
|Dilated collateral superficial veins (non-varicose)||+1|
|Past history of confirmed DVT||+1|
|Malignancy (including treatment up to six months previously)||+1|
|Intravenous drug use||+3|
|Alternative diagnosis more likely than DVT||-2|
|DVT "likely" if score >1|
|DVT "unlikely" if score <2|
Most studies give poor marks for Homans' sign, based on it being present in 33 percent of patients with true thrombosis and positive in greater than 50 percent of symptomatic patients without DVT.3 Venography is the reference standard for diagnosing DVT, but it is an invasive test that can be painful and is associated with allergic and other side effects. It should be reserved for patients having a high probability of the condition; other noninvasive tests, such as venous ultrasonography, impedance plethysmography4 and the D-dimer test, can often be used first for what are considered low-probability patients.
The D-dimer blood test, when negative, means it is most likely that the person tested does not have an acute condition or disease causing abnormal clot formation and breakdown. Most doctors agree that a negative D-dimer is most valid and useful when the test is done on people who are considered to be at low to intermediate risk for thrombosis. The test is used to help rule out clotting as the cause of symptoms.
In the case history described above, the lengthy plane ride was an important clue regarding potential DVT. We should tell our patients that regardless of the risk of DVT, they should avoid dehydration and frequently exercise their leg muscles. There is evidence that travelers on flights longer than six hours and with one or more risk factors for DVT should also consider knee-high graduated compression stockings, 15-30 mmHg at the ankle.
- Theiss JL, Fink ML, Gerber JP. Deep vein thrombosis in a young marathon athlete. JOSPT, 2011;41(12):942-947.
- Wells PA Anderson DR, Rodger M, et al. Derivation of a simple clinical model to categorize patient's probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost, 2000;83:416-420.
- Cranley JJ, Canos AJ, Sull WJ. The diagnosis of deep venous thrombosis. Fallibility of clinical symptoms and signs. Arch Surg, 1976;111:34-6.
- Lensing AWA, Hirsh J, Buller HR. Diagnosis of Venous Thrombosis. In: Colman RW, Hirsh J, Marder VJ, Salzman EW, editors. Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 3rd Edition. Philadelphia: JB Lippincott Co., 1994:1297-1321.
- Wells PS, Owen C, Doucette S, Fergusson D, Tran H. Does this patient have deep vein thrombosis? JAMA, Jan. 11, 2006;295(2):199-207.
- Scarvelis D, Wells PS. Diagnosis and treatment of deep-vein thrombosis. CMAJ, Oct. 24, 2006;175(9):1087-92. (Erratum in CMAJ, Nov. 20, 2007;177(11):1392.)
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