|Follow-Up Results From the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)|
|Glucosamine and chondroitin||0.194 mm|
A few months later, results of another two-year study was published.3 In that study, 622 patients with knee arthritis had randomly received either 800 mg of chondroitin sulfate or a placebo for two years. Radiographic analysis at baseline, 12 and 24 months was performed. After two years, the mean joint-space losses were as follows:
|Results From the Study on Osteoarthritis Progression Prevention|
|Chondroitin sulfate||0.070 mm|
The authors concluded that the radiographic progression of joint-space loss was reduced in patients who took chondroitin sulfate compared to those who took placebo. The authors also noted that pain was noticeably reduced in the chondroitin group. This conflicted with the conclusions of the GAIT extension, which, according to the authors, were statistically insignificant.
For some people, glucosamine and chondroitin will have varying degrees of benefit. Research has yet to determine who will be a responder, nor can we say if chondroitin, glucosamine or the combination of the two delivers the best results. Until that happens, the best advice we can give to our patients is to take a trial-and-error approach and stick to what works best.
- Sawitzke AD, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the Glucosamine/Chondroitin Arthritis Intervention Trial. Arthritis Rheumatol, 2008;58(10):3183-91.
- Andersen GD. "The Glucosamine/Chondroitin Arthritis Intervention Trial." Dynamic Chiropractic, May 8, 2006;24(13):18
- Kahan A, Uebelhart D, DeVathaire F, et al. Long-term effects of chondroitin (4 and 6 sulfate) on knee osteoarthritis: The Study on Osteoarthritis Progression Prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol, 2009;60(2):524-33.
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