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Neurogenic Inflammation, or Why a Tennis Elbow Did Not RespondBy Warren Hammer, MS, DC, DABCO Epicondylopathies (tennis elbow, golfer's elbow) usually fall into the realm of "tendinosis," which is a chronic pain syndrome with minimal to no inflammation. Why then do some cases persist with chronic pain and not respond to soft-tissue methods? Techniques such as friction massage, Active Release®, Graston Technique® and other methods often prove to be effective; then there are cases that do not respond and may necessitate surgery. There are a variety of possibilities, two of which may be just excessive tendinosis degeneration or neurogenic inflammation. This article will discuss the latter.We usually think of the primary afferent sensory fibers as only supplying the spinal cord with nociceptive stimuli, but these same fibers, when irritated, have efferent effects causing vasodilation, plasma extravasation, edema, hyperaemia and erythema. These nerves create this by releasing proinflammatory neuropeptides. Significant neuropeptides such as substance P (SP) and calcitonin gene-related peptide (CGRP) lead to what is known as neurogenic inflammation.1,2 Due to the fact that nearly all tissues in mammals, including humans, are innervated by afferent sensory neurons, this neurogenic inflammation can occur ubiquitously throughout the body.3 Ljung, Alfredson and Forsgren4 evaluated both the medial and lateral epicondyles and found out that the mechanical stress on the tendons attaching to the condyles stimulated a release of SP and CGRP, indicating a neurogenic inflammatory origin. Since inflammatory cells have not been utilized in histopathological studies of tendon insertions in epicondylopathies, it has been hard to explain why steroids at times reduce the pain. Because sensory nerve cells have glucocorticoid receptors, and steroids influence the effects and the levels of SP and CGRP, they are able to reduce neurogenic edema. The effect of soft-tissue methods on neurogenic involvement hopefully will be determined in the future. It has also been found that lumbosacral ligamentous structures have primary afferent fiber innervation and secret proinflammatory neuropeptides from their distal processes. This creates the neurogenic inflammatory processes5 that may explain chronic back pain.6 References
Warren Hammer, MS, DC, DABCO Click here for more information about Warren Hammer, MS, DC, DABCO.
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