Nutrient partitioning for metabolic up or down regulation took root from the fact that some drugs cause us to gain body fat without any dietary or exercise changes. Other drugs (beta adrenergicagonists) have increased lean body weight in animals without any diet or activity changes. Most of these drugs are used to treat asthma and have a host of other side effects when a healthy person takes them at levels to up regulate.
There are currently studies being conducted on how a protein species (specific combinations of amino acids with cofactors) can regulate carbon storage. That is, repartition calories slated for storage to muscle instead of fat. Consumption of this engineered food (needless to say, a closely guarded secret) at levels of 500 to 1000 calories a day could theoretically up regulate the system toward muscle protein storage (these calories are substituted, not added to normal daily intake). With requirements for energy remaining constant, the body would have to turn to fat stores or consume additional calories to make up the difference. Or, as Dr. Scott Connelly (the physician who originated this theory) states, "Protein accretion in muscle would occur at the expense of fat tissue storage."1 To make this work even better, it is recommended that one exercise the muscles with weight lifting or similar activities. For example, preliminary data demonstrates that the energy required to move 10 calories headed for fat storage to protein storage is 4 calories. According to Connelly, muscle tissue has carbon-trapping properties. Thus, when our energy requirements increase, the most accessible source of carbon atoms is body fat. Simply stated, we are storing less fat and burning more fat, both of which require additional energy and help raise our basal metabolic rates.
As ongoing research on this theory becomes available, I will make sure to keep you informed.
1. The Connelly Report. January 1994. Vol 1, No 1. Myosystems, Inc., Golden, Colorado.
G. Douglas Andersen, DC
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