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Reducing Inflammation with Proteolytic Enzymes, Part II: Common Uses, Safety, Weights and Measures, and DosingBy G. Douglas Andersen, DC, DACBSP, CCN Last month, in the first part of "Reducing Inflammation with Proteolytic Enzymes," we reviewed issues on absorption and the substances that proteolytic substances are derived from. This month,we will begin our discussion of proteolytic enzymes with a list of conditions commonly encountered in the chiropractic practice where proteolytic enzyme supplementation may be of benefit:Abrasions Safety After reviewing over 30 studies, Bucci stated that there were "more frequent side effects from placebos than from proteases."1 The most common negative side effects of proteolytic enzymes are gastrointestinal. A few people will complain of upset stomach or nausea when taking enzyme preparations. If this occurs: (1) ask the patient if they have a sensitivity to the source of the enzyme, for example, beef, pork, papaya, and pineapple; and (2) change formulas/brands.1Weights and Measures Weights and measures have been one of the biggest problems with the use of proteolytic enzymes. There are no uniform measurements of activity; thus, it is not possible to compare the strengths of different preparations or different types of enzymes. Common measurements used include United States Pharmacopeia (USP); Armour units, Rohrer units; milk clotting units (MCU); gelatin-dissolving units (GDU); and national formulary units (NF). There is no conversion equation to determine if 100 mg of brand A that has 500 MCU of potency is stronger or weaker that 50 mg of brand B that guarantees 1,000 USP of activity. To make matters worse, many brands are sold by their weight, which has nothing to do with how active the product is. Dosing
Until manufacturers can come up with uniform standards for clinicians to compare and recommend these products in a rational manner, utilization of enzymes will be continue to be less than it should be. I know of no other vitamin, mineral, herb or nutraceutical substance which the experts recommend to "take a bunch of pills four or five times a day." If you can get by the frustrating weight and measure issue, you will find that proteolytic enzymes can be a useful tool in your practice. Reference 1. Bucci L. Nutrition Applied to Injury Rehabilitation and Sports Medicine. Boca Raton, FL: CRC Press, 1995. Click here for more information about G. Douglas Andersen, DC, DACBSP, CCN.
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